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Preeclampsia and the risk of bronchopulmonary dysplasia in VLBW infants: a population based study

Ting-An Yen1, Hwai-I Yang, Wu-Shiun Hsieh

  • 1Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

Plos One
|September 28, 2013
PubMed

Insights

Maternal preeclampsia exposure was associated with a lower risk of bronchopulmonary dysplasia (BPD) in premature infants. This protective effect was observed in relatively mature very-low-birth-weight infants.

Area of Science:

  • Neonatalogy
  • Obstetrics
  • Perinatology

Background:

  • Preeclampsia is a major cause of maternal mortality and preterm birth.
  • Both preeclampsia and bronchopulmonary dysplasia (BPD) involve impaired angiogenesis.
  • The link between maternal preeclampsia and infant BPD is debated.

Purpose of the Study:

  • To investigate the association between maternal preeclampsia and the risk of BPD in very-low-birth-weight (VLBW) infants.
  • To clarify the controversial relationship between preeclampsia and BPD.

Main Methods:

  • Retrospective cohort study of 5,753 VLBW infants in Taiwan (1997-2006).
  • BPD defined as oxygen dependence at 36 weeks postmenstrual age.
  • Multivariate logistic regression analysis used to assess the association.

Main Results:

  • Maternal preeclampsia incidence was 14.7%; overall BPD incidence was 34.9%.
  • Infants exposed to preeclampsia had lower BPD rates (24.1% vs. 36.7%; aOR 0.78).
  • The association was significant in VLBW infants with gestational age 31-34 weeks.

Conclusions:

  • Fetal exposure to maternal preeclampsia is linked to a reduced risk of BPD.
  • This protective association is notable in relatively mature VLBW infants.
Abstract

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