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Related Experiment Videos

Transmissible encephalopathies in animals.

R H Kimberlin1

  • 1Institute for Animal Health, AFRC & MRC Neuropathogenesis Unit, Edinburgh, United Kingdom.

Canadian Journal of Veterinary Research = Revue Canadienne De Recherche Veterinaire
|January 1, 1990
PubMed
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Scrapie, a transmissible encephalopathy, persists in flocks due to maternal transmission and long incubation. Genetic markers in sheep (Sip gene) and mice (Sinc gene) offer potential for disease control.

Area of Science:

  • Veterinary Neurology
  • Infectious Diseases
  • Genetics

Background:

  • Scrapie is a well-known transmissible spongiform encephalopathy affecting sheep and goats.
  • Maternal transmission and extended incubation periods are key factors in maintaining scrapie within animal populations.
  • Scrapie-like diseases have been identified in other ruminants and mink, potentially linked to contaminated animal feed.

Purpose of the Study:

  • To explore the genetic basis of scrapie susceptibility and transmission.
  • To investigate the mechanisms of neuroinvasion and disease progression in experimental scrapie models.
  • To discuss the implications of animal scrapie for human health.

Main Methods:

  • Analysis of sheep and rodent models of scrapie.

Related Experiment Videos

  • Identification and study of genetic markers (Sip and Sinc genes).
  • Investigation of prion protein (PrP) and scrapie-associated fibrils.

    • Main Results:

    • A single sheep gene (Sip) influences both natural and experimental scrapie.
    • Neuroinvasion in rodents involves spread from lymphoreticular tissues via nerves.
    • Disease progression is slowed by replication and cell-to-cell spread restrictions, likely controlled by the Sinc gene in mice.
    • The glycoprotein PrP is implicated as the normal product of the Sinc gene and a component of the infectious agent.

    Conclusions:

    • Genetic selection using allelic markers of the Sip gene could aid in controlling natural scrapie.
    • Understanding the Sinc gene's role in mice provides insights into scrapie pathogenesis.
    • The potential for cross-species transmission through contaminated feed warrants consideration for human health.