Boosting anticancer vaccines: Too much of a good thing?
Alessia Ricupito1, Matteo Grioni, Arianna Calcinotto
1Cellular Immunology Unit; San Raffaele Scientific Institute; Milan, Italy.
Abstract:
Using both transplantable and oncogene-driven autochthonous tumor models challenged with dendritic cell-based vaccines, we have recently found that boosting provides a clear advantage in prophylactic settings, unless performed on an excessively tight schedule, which causes the loss of central memory T cells. In therapeutic settings, boosting turned out to be always detrimental.
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