Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-Omics Analysis Defines Endotypes and Systemic Inflammation in Primary Ciliary Dyskinesia: A Comparison with Healthy Controls.

Annals of the American Thoracic Society·2026
Same author

Heterogeneity and clinical relevance of group 2 innate lymphoid cells subsets in nasal polyps.

The Journal of allergy and clinical immunology·2026
Same author

From wrist data to lifespan: elucidating inflammation-driven biological aging via activity rhythms captured by wearable devices.

npj aging·2026
Same author

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors.

International forum of allergy & rhinology·2026
Same author

The concept of environmental injustice in allergy and asthma.

Current opinion in allergy and clinical immunology·2025
Same author

The age of eczema onset and multiple food allergies.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2025

Related Experiment Video

Updated: May 7, 2026

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

Chronic rhinosinusitis and age: is the pathogenesis different?

Mahboobeh Mahdavinia1, Leslie C Grammer

  • 1Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Expert Review of Anti-Infective Therapy
|October 1, 2013
PubMed
Summary

Chronic rhinosinusitis (CRS) presents differently in children and adults, affecting symptoms, tissue characteristics, and related conditions. Understanding these pediatric versus adult CRS distinctions is key for effective management.

More Related Videos

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
09:02

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Published on: September 22, 2023

Related Experiment Videos

Last Updated: May 7, 2026

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
09:02

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Published on: September 22, 2023

Area of Science:

  • Otolaryngology
  • Pediatric Medicine
  • Immunology

Background:

  • Chronic rhinosinusitis (CRS) is a prevalent condition impacting quality of life across all age groups.
  • Significant differences exist in symptomatology, histopathology, and associated comorbidities between pediatric and adult CRS patients.
  • Existing research highlights a need for better understanding of age-specific CRS characteristics.

Purpose of the Study:

  • To delineate the key differences in chronic rhinosinusitis (CRS) between pediatric and adult populations.
  • To compare symptomatology, histopathological findings, and associated diseases in pediatric versus adult CRS.
  • To identify age-specific factors influencing CRS presentation and management.

Main Methods:

  • Comparative analysis of existing literature on pediatric and adult chronic rhinosinusitis (CRS).
  • Review of studies focusing on symptomatology, histopathology (e.g., cellularity, infiltration, glandular hyperplasia), and comorbidities.
  • Synthesis of data regarding the role of specific conditions like nasal polyposis, cystic fibrosis, allergic fungal rhinosinusitis, gastroesophageal reflux disease, otitis media, adenoids, immunodeficiencies, and asthma in different age groups.

Main Results:

  • Nasal polyposis is less common in pediatric CRS, except in cases of cystic fibrosis or allergic fungal rhinosinusitis.
  • Pediatric CRS shows higher cellularity and lymphocytic infiltration, while adult CRS exhibits more eosinophilic infiltration and glandular hyperplasia.
  • Stronger associations are noted between pediatric CRS and gastroesophageal reflux disease, otitis media, and potentially adenoids, whereas immunodeficiencies and asthma are common across all ages.

Conclusions:

  • Significant age-related disparities exist in the clinical presentation, underlying pathology, and associated conditions of chronic rhinosinusitis (CRS).
  • These differences underscore the importance of age-specific diagnostic and therapeutic approaches for CRS.
  • Further research is needed, particularly on the pathophysiology of CRS in the elderly population.