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Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
What is the Cell Cycle?00:56

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...

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Updated: May 7, 2026

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
08:52

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

Published on: August 16, 2015

Connecting the cell cycle with cellular identity.

Gloryn Chia1, Dieter Egli

  • 11 Department of Pediatrics, Naomi Berric Diabetes Center, Columbia University , New York, NY 10032.

Cellular Reprogramming
|October 1, 2013
PubMed
Summary
This summary is machine-generated.

Oocyte reprogramming restores totipotency, enabling cloning and stem cell generation. This review explores the cell cycle

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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

Related Experiment Videos

Last Updated: May 7, 2026

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
08:52

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

Published on: August 16, 2015

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
08:33

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

Area of Science:

  • Reproductive biology and developmental science.
  • Cellular reprogramming and stem cell biology.
  • Molecular and developmental mechanisms.

Background:

  • Oocytes possess a unique ability to reprogram somatic cells to a totipotent state, crucial for cloning and stem cell generation.
  • Understanding the molecular intricacies of oocyte reprogramming post-nuclear transfer remains a significant scientific challenge.
  • Existing molecular analyses often lack functional context for complex processes like chromatin dynamics and DNA replication.

Purpose of the Study:

  • To bridge the gap between nuclear transfer techniques and molecular biology insights.
  • To elucidate the critical role of the cell cycle in the reprogramming of somatic cells within oocytes.
  • To provide a comprehensive overview of cell cycle-mediated reprogramming mechanisms.

Main Methods:

  • Review of existing literature on nuclear transfer, oocyte biology, and cell cycle regulation.
  • Analysis of molecular mechanisms involved in chromatin remodeling and gene expression during reprogramming.
  • Integration of findings to highlight the cell cycle's influence on reprogramming efficiency and outcomes.

Main Results:

  • The cell cycle is a central orchestrator of the reprogramming process following nuclear transfer.
  • Specific cell cycle phases and regulatory events dictate the accessibility of the somatic nucleus to oocyte factors.
  • Cell cycle progression influences chromatin modifications and DNA replication, essential for establishing totipotency.

Conclusions:

  • The cell cycle is a key determinant of successful oocyte reprogramming and subsequent totipotency.
  • Targeting cell cycle regulation offers potential strategies to improve cloning efficiency and stem cell derivation.
  • A deeper understanding of cell cycle dynamics is vital for advancing reproductive technologies and regenerative medicine.