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Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

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Related Experiment Video

Updated: May 7, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

[Regional migrating osteoporosis - a case report].

I Zofková, J Hrbáč, J Dostál

Vnitrni Lekarstvi

|October 1, 2013

Summary

Regional migrating osteoporosis (RMO) is a rare condition causing temporary bone pain in young adults. This study highlights its migratory pattern and diagnostic imaging findings, emphasizing the need to rule out other bone pathologies.

Area of Science:

Orthopedics
Radiology
Bone Metabolism

Background:

Regional migrating osteoporosis (RMO) is an uncommon condition characterized by episodic bone pain.
The pain typically affects weight-bearing joints and exhibits a migratory pattern.

Purpose of the Study:

To describe the clinical presentation and diagnostic imaging findings of RMO.
To differentiate RMO from other bone pathologies like infection or avascular necrosis.

Main Methods:

Case report of a young male patient with RMO.
Diagnostic imaging included dynamic scintigraphy (SPECT) and magnetic resonance imaging (MRI).

Main Results:

SPECT revealed increased radioisotope accumulation in the hip, leg, and knee joints due to hyperperfusion and high metabolic activity.

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Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

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Last Updated: May 7, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

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Published on: September 8, 2023

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

MRI confirmed bone marrow edema in the affected unilateral skeletal regions.

Conclusions:

RMO presents with migratory bone pain and characteristic imaging findings of hyperperfusion and bone marrow edema.
While generally benign with spontaneous resolution, RMO diagnosis requires excluding infectious etiologies and avascular necrosis.