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Recessed ring-disk nanoelectrode arrays integrated in nanofluidic structures for selective electrochemical detection
Chaoxiong Ma1, Nicholas M Contento, Larry R Gibson
1Department of Chemistry and Biochemistry, and ‡Department of Chemical and Biomolecular Engineering, University of Notre Dame , Notre Dame, Indiana 46556, United States.
Analytical Chemistry
|October 1, 2013
Summary
Recessed ring-disk electrode arrays in nanofluidic channels enhance selectivity for electrochemical analysis. This method improves detection of electroactive species like dopamine by minimizing interference from other compounds.
Area of Science:
- Electrochemistry
- Nanotechnology
- Analytical Chemistry
Background:
- Recessed ring-disk (RRD) electrode arrays exhibit redox cycling for current amplification.
- Nanofluidic channels offer unique environments for electrochemical analysis.
- Selective detection of electroactive species is crucial in complex mixtures.
Purpose of the Study:
- To integrate RRD electrode arrays into nanofluidic channels for enhanced electrochemical analysis.
- To improve the selectivity and sensitivity of detecting electroactive species.
- To demonstrate interference-free determination of analytes in complex biological samples.
Main Methods:
- Fabrication of RRD electrode arrays using multilayer deposition, nanosphere lithography, and reactive ion etching.
- Integration of RRD arrays into nanofluidic channels.
- Cyclic voltammetry for electrochemical analysis of redox species.
Main Results:
- Integration into nanofluidic channels improved selectivity for Ru(NH3)6(3+) against ascorbic acid from ~10 to ~70.
- Interference-free determination of dopamine in the presence of a 100-fold excess of ascorbic acid was achieved.
- Selective detection of species with resolved and overlapping redox potentials was demonstrated.
Conclusions:
- Nanofluidic confinement significantly enhances the selectivity of RRD electrode arrays.
- RRD arrays integrated with nanofluidics provide a powerful platform for selective electrochemical analysis.
- This technology enables sensitive and interference-free detection of important analytes.
