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CD31 expression in plasmacytic/plasmablastic lesions.

Elizabeth Plocharczyk1, Paul E Wakely

  • 1Department of Pathology, Wexner Medical Center at The Ohio State University, Columbus, OH 43210, USA.

Annals of Diagnostic Pathology
|October 1, 2013
PubMed
Summary
This summary is machine-generated.

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CD31 is not exclusively specific to endothelial cells and can be present in plasmacytic lesions. This finding is crucial for accurately diagnosing vascular neoplasms and plasmablastic myeloma.

Area of Science:

  • Oncology
  • Pathology
  • Immunohistochemistry

Background:

  • CD31 is a widely used marker for identifying endothelial cells and diagnosing vascular tumors.
  • However, the specificity of CD31 in distinguishing between vascular neoplasms and other malignancies is not absolute.

Purpose of the Study:

  • To investigate the expression of CD31 in various plasmacytic lesions.
  • To assess the diagnostic implications of CD31 positivity in differentiating vascular neoplasms from plasmablastic malignancies.

Main Methods:

  • Analysis of CD31 immunohistochemical staining in 34 plasmacytic lesions.
  • Inclusion of plasma cell myelomas, extraosseous plasmacytoma, plasmablastic variants of myeloma, plasmablastic non-Hodgkin lymphomas, and reactive plasmacytic infiltrates.
  • ERG staining was performed for comparison.
Keywords:
CD31Plasma cellsPlasmablastic lymphomaPlasmablastic myeloma

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Main Results:

  • CD31 positivity was observed in all reactive plasma cellular infiltrates, 93% of plasma cell myelomas, 80% of plasmablastic variants of myeloma, and 20% of plasmablastic non-Hodgkin lymphomas.
  • Staining was typically diffuse and strong membranous.
  • No cases showed positive ERG staining.

Conclusions:

  • CD31 is expressed in a significant proportion of plasmacytic lesions, challenging its exclusive role as an endothelial marker.
  • Plasmablastic variant of myeloma can exhibit CD31 positivity, potentially leading to misdiagnosis as a vascular neoplasm.
  • Careful interpretation of CD31 staining, alongside other markers like ERG, is essential for accurate oncologic diagnosis.