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Cerebral organoids in a dish: progress and prospects
Marina Bershteyn1, Arnold R Kriegstein
1Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, 35 Medical Center Way, San Francisco, CA 94143, USA; University of California, San Francisco, San Francisco, CA 94143, USA.
Cell
|October 1, 2013
Summary
Scientists developed a novel method to grow three-dimensional cerebral organoids from pluripotent stem cells. These brain organoids were used to successfully model microcephaly, a human neurological disorder.
Area of Science:
- Neuroscience
- Developmental Biology
- Stem Cell Biology
Background:
- Three-dimensional (3D) cultures of cortical tissues offer a promising avenue for studying human brain development and associated disorders.
- Pluripotent stem cells provide a renewable source for generating these complex tissue models.
Purpose of the Study:
- To introduce a new method for generating cerebral organoids in vitro.
- To utilize these cerebral organoids to model the human brain disorder microcephaly.
Main Methods:
- Generation of cerebral organoids using a novel 3D culture technique.
- Derivation of organoids from pluripotent stem cells.
- Application of the model to study microcephaly.
Main Results:
- Successful generation of cerebral organoids that mimic aspects of human brain development.
- Demonstration of the model's utility in studying microcephaly.
- Insights into the developmental processes underlying microcephaly.
Conclusions:
- The novel method enables the creation of advanced cerebral organoids for studying brain development.
- Cerebral organoids serve as a valuable platform for modeling neurological disorders like microcephaly.
- This approach holds potential for advancing our understanding of human brain disorders and facilitating drug discovery.
