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Spontaneous methicillin-sensitive Staphylococcus aureus spondylodiscitis-Short course antibiotic therapy may be

Thomas Locke1, Megan E Kell1, Debapriya Bhattacharyya2

  • 1Department of Infection and Tropical Medicine, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom.

Journal of Infection and Public Health
|October 1, 2013
PubMed

Insights

Methicillin-sensitive Staphylococcus aureus spondylodiscitis management varies widely. Most patients improved with diverse antibiotic regimens, suggesting a need for standardized treatment guidelines.

Area of Science:

  • Infectious Diseases
  • Orthopedics
  • Pharmacology

Background:

  • Spontaneous methicillin-sensitive Staphylococcus aureus spondylodiscitis is rising.
  • Optimal management strategies lack consensus.

Purpose of the Study:

  • To analyze antimicrobial therapy and outcomes for Staphylococcus aureus spondylodiscitis.
  • To evaluate treatment variations and patient outcomes over seven years.

Main Methods:

  • Retrospective analysis of 55 patients with Staphylococcus aureus spondylodiscitis.
  • Review of antimicrobial therapy duration, route (intravenous vs. oral), and treatment regimens.
  • Assessment of patient outcomes at latest follow-up.

Main Results:

  • A median of 12 weeks of antibiotics was used (6 weeks IV, 9 weeks oral).
  • 23 different treatment regimens were identified.
  • 92% of patients (33/36) showed cure or improvement, irrespective of therapy duration or IV proportion.

Conclusions:

  • Significant variation exists in antibiotic prescribing for Staphylococcus aureus spondylodiscitis.
  • Positive patient outcomes were observed across diverse treatment approaches.
  • Further multi-center randomized controlled trials are needed to establish optimal treatment strategies.
Keywords:
Antibacterial agentsMethicillin-sensitive Staphylococcus aureusSpondylodiscitis

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