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Related Experiment Video

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Protocol to Create Chronic Wounds in Diabetic Mice

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Published on: September 25, 2019

Neoplastic wounds and degenerescence.

S Meaume¹, I Fromantin, Luc Teot

¹Wound Healing Unit, Geriatric and Dermatologic Center, Hôpital Rothschild, 7, Rue de Santerre, 75012 Paris, France.

Journal of Tissue Viability

|October 1, 2013

Summary

Malignant wounds affect 5-10% of cancer patients, including rare Marjolin's ulcers arising from chronic wounds. Early diagnosis via systematic biopsy of persistent wounds is crucial for managing these rare skin cancers.

Keywords:

Marjolin's ulcer Neoplastic wounds Squamous cell carcinoma malignant wound

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Area of Science:

Oncology
Dermatology
Pathology

Background:

Malignant wounds complicate 5-10% of cancer cases, presenting as invasive skin lesions.
Marjolin's ulcers are rare malignancies developing in chronic wounds, scars, or inflamed skin.
These ulcers can transform into squamous cell carcinoma, melanoma, or other cancers.

Purpose of the Study:

To review the occurrence and characteristics of malignant wounds and Marjolin's ulcers.
To highlight the association between chronic wounds and secondary malignancies.
To emphasize the need for improved diagnosis and data collection.

Main Methods:

Literature review of malignant transformation in chronic wounds.
Analysis of clinical presentations and associated conditions.
Discussion of diagnostic criteria and epidemiological gaps.

Main Results:

Marjolin's ulcers arise from chronic inflammation or scarring, with squamous cell carcinoma being common.
Specific associations include chronic ulcers, burn scars, and venous insufficiency.
Epidermoid carcinomas are found in 0.21-0.34% of leg ulcers, but data is limited.

Conclusions:

Malignant transformation of chronic wounds necessitates clinical vigilance.
Systematic biopsy of chronically open wounds is recommended for early diagnosis.
Further epidemiological studies are needed to address data deficiencies.