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Updated: May 5, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

Basophils and allergic inflammation.

Mark C Siracusa¹, Brian S Kim, Jonathan M Spergel

¹Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa.

The Journal of Allergy and Clinical Immunology

|October 1, 2013

Summary

This summary is machine-generated.

Basophils, though rare, are crucial in allergic inflammation by mediating TH2 cytokine responses. Targeting these cells offers potential therapeutic strategies for allergic diseases.

Keywords:

AD APC AR Allergic rhinitis Antigen-presenting cell Atopic dermatitis BAT BaP Basophil Basophil activation test Basophil precursor CIU Chronic idiopathic urticaria EMH EoE Eosinophilic esophagitis Extramedullary hematopoiesis FDA GMP Granulocyte-monocyte progenitor HDM HSC Hematopoietic stem cell House dust mite IgE LTC(4)Leukotriene C(4)MCP Mast cell precursor MyD88 Myeloid differentiation primary response gene (88)T(H)2 cytokine TSLP Thymic stromal lymphopoietin US Food and Drug Administration allergic rhinitis allergy asthma atopic dermatitis eosinophilic esophagitis food allergy thymic stromal lymphopoietin urticaria

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Last Updated: May 5, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

Basophil Activation Test for Allergy Diagnosis

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Published on: May 31, 2021

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Area of Science:

Immunology
Allergy Research

Background:

Basophils, the least abundant granulocytes, were historically overlooked due to rarity and similarity to mast cells.
Recent research highlights their significant, nonredundant roles in TH2 cytokine-mediated inflammation.

Purpose of the Study:

To provide a historical perspective on basophil research.
To discuss recent findings on basophil regulation, function, and therapeutic potential in allergic inflammation.

Main Methods:

Review of recent genetic approaches and experimental studies in human and murine models.
Analysis of molecular pathways regulating basophil development, activation, and effector functions.

Main Results:

Basophils migrate into lymphoid tissues and cooperate with other immune cells.
They play a significant role in the development and progression of TH2-mediated allergic inflammation.

Conclusions:

Basophils possess unique effector functions critical to allergic inflammation pathogenesis.
Targeting basophils presents a promising therapeutic avenue for allergic diseases.