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Related Concept Videos

Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...

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Related Experiment Video

Updated: May 7, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Serum low density lipoprotein subclasses in asthma.

Nicola Scichilone1, Manfredi Rizzo, Alida Benfante

  • 1BioMedical Department of Internal Medicine and Medical Specialties (DiBiMIS), University of Palermo, Italy; Euro-Mediterranean Institute of Science and Technology, Italy.

Respiratory Medicine
|October 1, 2013
PubMed
Summary
This summary is machine-generated.

Low-density lipoprotein (LDL) subclasses may play a role in asthma. Smaller, more inflammatory LDL particles were linked to reduced lung function in asthmatics, suggesting a connection between dyslipidemia and asthma severity.

Keywords:
Asthma pathogenesisDyslipidemiaFEV(1)LDL subclasses

Related Experiment Videos

Last Updated: May 7, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Area of Science:

  • Pulmonary Medicine
  • Cardiovascular Research
  • Immunology

Background:

  • Serum low-density lipoproteins (LDL) are implicated in asthma inflammation.
  • Recent research suggests LDL may influence airway inflammation in human asthma.

Purpose of the Study:

  • To investigate the association between LDL subclasses and the occurrence/severity of asthma.

Main Methods:

  • Compared LDL subclasses in 24 asthmatics and 24 healthy controls.
  • Utilized the LipoPrint System to analyze LDL subclasses (large: LDL-1, -2; small/pro-inflammatory: LDL-3 to -7).

Main Results:

  • Asthmatics had significantly lower levels of large LDL-2 compared to controls.
  • Smaller LDL subclasses (LDL-4 to -7) were undetectable in controls.
  • In asthmatics, larger LDL-1 correlated positively with lung function (VC%, FEV1%), while smaller LDL-3 correlated inversely.

Conclusions:

  • This pilot study suggests a potential role for LDL subclasses in asthma.
  • Larger studies are recommended to confirm the link between asthma and dyslipidemia.