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Hematopoietic defects and iPSC disease modeling: lessons learned

James M Kelley1, George Q Daley

  • 1Department of Pathology, Brigham and Women's Hospital/Harvard Medical School, Boston, MA 02115, USA.

Immunology Letters
|October 1, 2013
PubMed

Hematopoiesis is a paradigm for stem cell biology in that it centers on differentiation of a self-renewing pluripotent precursor into multiple committed cell types with specific functions. The use of induced pluripotent stem cells (iPSCs) as a disease modeling tool has revealed numerous insights into the underlying pathophysiology of hematological diseases - those disorders arising from defective hematopoiesis. Likewise, studying hematopoiesis and the defects that can arise offer clues to understanding general stem cell survival and differentiation.

Keywords:
Bone marrow failureDisease modelingInduced pluripotent stem cellsReprogramming

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