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Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
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Enhanced temporal pain processing in multiple system atrophy.

Armando Perrotta1, Monica Bolla, Mariano Serrao

  • 1IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy.

Neuroscience Letters
|October 1, 2013
PubMed
Summary
This summary is machine-generated.

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Multiple system atrophy (MSA) and Parkinson's disease (PD) patients exhibit abnormal pain processing due to striatonigral neurodegeneration. This facilitated pain response is similar in both conditions, suggesting a common underlying mechanism.

Area of Science:

  • Neuroscience
  • Neurology
  • Pain Research

Background:

  • Pain processing is understudied in multiple system atrophy (MSA), despite frequent patient complaints.
  • Striatonigral degeneration in basal ganglia disorders is linked to abnormal pain processing.
  • This study investigates pain processing in MSA, particularly in those with parkinsonian signs.

Purpose of the Study:

  • To investigate abnormal pain processing in multiple system atrophy (MSA).
  • To compare pain processing in MSA patients with Parkinson's disease (PD) patients and healthy controls.
  • To evaluate the effect of l-Dopa treatment on pain processing in MSA and PD.

Main Methods:

  • Evaluated temporal pain processing using the temporal summation threshold (TST) of the nociceptive withdrawal reflex (NWR).
Keywords:
Multiple system atrophyNociceptive withdrawal reflexPainTemporal summation

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  • Compared 11 MSA subjects, 15 PD subjects (on/off l-Dopa), and 15 healthy controls.
  • Assessed both neurophysiological and pharmacological responses related to pain.

    • Main Results:

    • MSA subjects demonstrated a significantly reduced NWR TST compared to healthy subjects.
    • MSA patients exhibited facilitated pain responses, similar to PD patients.
    • No significant differences in pain processing were found between 'on' and 'off' l-Dopa states, or between MSA and PD groups.

    Conclusions:

    • Multiple system atrophy (MSA) is associated with facilitated temporal pain processing, similar to Parkinson's disease (PD).
    • Abnormal pain processing in MSA and PD may stem from striatonigral neurodegeneration.
    • This neurodegeneration could increase susceptibility to developing pain conditions in these patient groups.