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Related Experiment Video

Updated: May 7, 2026

Inkjet-printed Polyvinyl Alcohol Multilayers

Inkjet-printed Polyvinyl Alcohol Multilayers

Published on: May 11, 2017

Polyvinyl acetate-based film coatings.

K Kolter¹, A Dashevsky, Muhamad Irfan

¹BASF SE, Development Pharma Ingredients, Ludwigshafen, Germany.

International Journal of Pharmaceutics

|October 1, 2013

Summary

Polyvinyl acetate (Kollicoat® SR 30 D) offers pH-independent controlled drug release coatings. Its properties allow easy processing and adjustable drug release, presenting a novel alternative to OROS systems.

Keywords:

Aqueous colloidal polymer dispersions Compaction of pellets Curing Extended release Kollicoat(®) SR 30 D OROS

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Area of Science:

Pharmaceutical technology
Materials science

Background:

Kollicoat® SR 30 D is a polyvinyl acetate-based polymer dispersion used for controlled drug release coatings.
It exhibits moderate swelling, lipophilicity, and pH-independent permeability, along with high flexibility.
Its low minimum film forming temperature (MFT) of 18°C facilitates processing without plasticizers.

Purpose of the Study:

To evaluate Kollicoat® SR 30 D for controlled release coating applications.
To investigate the influence of formulation variables on drug release profiles.
To explore its potential as an alternative to osmotic drug delivery systems.

Main Methods:

Coating of pellets with Kollicoat® SR 30 D.
Assessment of film properties including swelling, lipophilicity, and flexibility.
Drug release studies under various conditions (pH, coating level, excipients).
Evaluation of plasticizer and pore-former effects on film and release characteristics.

Main Results:

Kollicoat® SR 30 D coatings demonstrated pH-independent drug release.
Drug release was controllable via coating level and addition of pore-forming polymers (Kollidon® 30, Kollicoat® IR).
Addition of triethyl citrate improved film flexibility and allowed for tablet compaction with minimal impact on drug release.

Conclusions:

Kollicoat® SR 30 D is a versatile polymer for developing controlled-release dosage forms with pH-independent drug release.
Formulation adjustments, including plasticizers and pore formers, effectively modulate drug release kinetics.
Combinations with Kollicoat® IR offer a promising, drill-free alternative to OROS systems for controlled drug delivery.