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Updated: May 7, 2026

Generation of Natural Killer Cells from Human Expanded Potential Stem Cells
Published on: January 13, 2023
Understanding human NK cell differentiation: clues for improving the haploidentical hematopoietic stem cell
Elisa Montaldo1, Paola Vacca, Lorenzo Moretta
1Department of Experimental Medicine, University of Genova, Genova, Italy.
Abstract:
The study of in vitro and in vivo NK cell differentiation from hematopoietic precursors revealed the existence of discrete stages of development. These stages are characterized by the progressive acquisition of markers and receptors that play a crucial role in NK cell function. The knowledge acquired has revealed particularly relevant for improving the HSCT to cure high-risk leukemias in the haplo-HSCT setting, in which NK cells play a central role in the clearance of leukemic cells and in the positive clinical outcome.
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