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09:05
MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
IFITMs restrict the replication of multiple pathogenic viruses
Jill M Perreira1, Christopher R Chin, Eric M Feeley
1Microbiology and Physiological Systems (MaPS) Department, University of Massachusetts Medical School, Albert Sherman Center 8 1001, 368 Plantation Street, Worcester, MA 01655, USA.
Journal of Molecular Biology
|October 1, 2013
Abstract:
The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic viruses, among them influenza A virus, dengue virus, hepatitis C virus, and Ebola virus. This review covers recent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of action, and impact on pathogenesis.
Insights
Interferon-inducible transmembrane proteins (IFITM) are key antiviral proteins that restrict viruses like influenza and Ebola. This review details IFITM
Area of Science:
- Virology
- Immunology
- Molecular Biology
Background:
- The interferon-inducible transmembrane protein (IFITM) family plays a crucial role in innate immunity.
- IFITM proteins are known to restrict a broad spectrum of viruses, including influenza A virus, dengue virus, hepatitis C virus, and Ebola virus.
Purpose of the Study:
- To review recent advancements in understanding the molecular determinants of IFITM proteins.
- To explore the potential mechanisms by which IFITM proteins exert their antiviral activity.
- To discuss the impact of IFITM proteins on viral pathogenesis.
Main Methods:
- Literature review of recent scientific publications.
- Analysis of studies investigating IFITM protein structure and function.
- Synthesis of data on viral restriction mechanisms and pathogenesis.
Main Results:
- Recent studies have identified key molecular features of IFITM proteins responsible for antiviral activity.
- Multiple mechanisms of action are proposed, including membrane disruption and interference with viral entry.
- IFITM proteins significantly influence the pathogenesis of various viral infections.
Conclusions:
- IFITM proteins represent a critical host defense mechanism against a wide range of viruses.
- Further research into IFITM molecular biology and antiviral mechanisms holds promise for therapeutic strategies.
- Understanding IFITM's role in pathogenesis is vital for controlling viral diseases.
Keywords:
ASCCHFVCD225 familyCILCMEMCrimean Congo hemorrhagic fever virusDENVEBOVEbola virusGPHCVHIV-1IAVIFITMIFNJSRVJaagsiekte sheep retrovirusMARVMLVMSMarburg virusMoloney leukemia virusN-terminal domainNTDOSBPRVFVRift Valley fever virusSARS CoVSeVSendai virusVAPAalanine scanningclathrin-mediated endocytosis motifconserved intracellular loopdengue virusglycoproteinhepatitis C virushost virus interactionshuman immunodeficiency virus type 1influenza A virusinterferoninterferon effector genesinterferon-inducible transmembrane proteinmass spectrometryoxysterol binding proteinrestriction factorsevere acute respiratory syndrome coronavirusvesicle-associated membrane protein-A
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