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Published on: November 5, 2021
Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole
Sara Braga Honorato1, Jorge Souza Mendonça, Nubia Boechat
1Departamento de Física, Universidade Federal do Ceará, CP 6030, Fortaleza, Ceará 60455-760, Brazil.
Abstract:
Benznidazole (N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide), is a nitro-heterocyclic drug used in the treatment of Chagas disease. Despite the fact that this drug was released more than 30 years ago, little information about its solid state properties is available in the literature. In this study, it was verified that this drug exhibits three polymorphs, which were characterized in situ by X-ray powder diffraction, thermal analysis, hot stage microscopy and infrared spectroscopy. The thermodynamic relationships among these polymorphs were also discussed.
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