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Related Experiment Video

Updated: May 7, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

Left atrial appendage occlusion: opportunities and challenges.

David R Holmes1, Dhanunjaya R Lakkireddy2, Richard P Whitlock3

  • 1Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.

Journal of the American College of Cardiology
|October 1, 2013
PubMed
Summary

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Left atrial appendage occlusion offers a stroke prevention alternative for patients with atrial fibrillation, potentially avoiding anticoagulation. Ongoing research supports its role in carefully selected individuals.

Area of Science:

  • Cardiology
  • Medical Devices
  • Stroke Prevention

Background:

  • Atrial fibrillation incidence is rising, increasing stroke risk.
  • Anticoagulation is standard for stroke prevention but has limitations.
  • Left atrial appendage thrombus is a common cause of stroke in atrial fibrillation.

Purpose of the Study:

  • To evaluate left atrial appendage occlusion as an alternative to anticoagulation for stroke prevention in nonvalvular atrial fibrillation.
  • To address challenges in regulatory approval for left atrial appendage occlusion devices.
  • To assess the safety and efficacy of mechanical left atrial appendage exclusion.

Main Methods:

  • Review of data from randomized trials and registries.
  • Analysis of catheter-based and surgical left atrial appendage occlusion techniques.
Keywords:
AFCIINRLAANOACRRWatchman deviceatrial fibrillationconfidence intervalinternational normalized ratio(s)left atrial appendageleft atrial appendage occlusionnonvalvular atrial fibrillationnovel oral anticoagulantrate ratiostroke prevention

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Last Updated: May 7, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

  • Evaluation of trial design, risk-benefit ratios, patient selection, and endpoints.

    • Main Results:

    • Accumulating data support left atrial appendage exclusion as a viable stroke prevention strategy.
    • Longer-term follow-up data are crucial for device approval and clinical adoption.
    • Carefully selected patients may benefit from this alternative to anticoagulation.

    Conclusions:

    • Left atrial appendage occlusion is a promising alternative to anticoagulation for stroke prevention in select atrial fibrillation patients.
    • Continued research and optimized trial designs are needed to overcome regulatory hurdles.
    • Mechanical exclusion of the left atrial appendage may reduce stroke risk without systemic anticoagulation.