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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.

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Related Experiment Video

Updated: May 7, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Mapping the p53 transcriptome universe using p53 natural polymorphs.

B Wang1, D Niu1, T H Lam2

  • 1Singapore Immunology Network, A*STAR, 8A Biomedical Grove, 138648 Singapore.

Cell Death and Differentiation
|October 1, 2013
PubMed
Summary
This summary is machine-generated.

This study identifies novel p53 gene targets using single-nucleotide polymorphism (SNP) variants. The findings reveal p53

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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

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Related Experiment Videos

Last Updated: May 7, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • The tumor suppressor p53 is crucial for cellular processes like apoptosis and DNA repair.
  • Existing genomic methods have identified numerous potential p53 targets, but validation is needed.

Purpose of the Study:

  • To systematically identify and validate novel transcriptional targets of the tumor suppressor p53.
  • To investigate p53's function in diverse cellular pathways.

Main Methods:

  • Developed a method using 16 non-synonymous p53 single-nucleotide polymorphism (SNP) variants.
  • Integrated p53 ChIP-seq analysis with transcriptome data from p53 SNP variants.

Main Results:

  • Identified 5 functionally null p53 SNPs and 11 p53 wild-type-like SNPs.
  • Discovered 592 novel p53 target genes by integrating ChIP-seq and transcriptome data.
  • These novel targets are involved in cell signaling, metabolism, CNS, and immune system functions.

Conclusions:

  • The study provides a robust method for validating p53 transcriptional targets.
  • Reveals p53's involvement in a broader range of physiological processes than previously understood.
  • Opens new research avenues for p53 function in normal and disease states.