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Related Experiment Videos

Endogenous opioid peptides and epilepsy.

K Ramabadran1, M Bansinath

  • 1Clinical Research Department #426, Abbott Laboratories, Abbott Park, IL 60064-3500.

International Journal of Clinical Pharmacology, Therapy, and Toxicology
|February 1, 1990
PubMed
Summary

Endogenous opioid peptides, like enkephalins, play a role in epilepsy. Further research is crucial to understand their function in epilepsy pathophysiology and treatment.

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Opiate receptors discovered in 1973.
  • Endogenous opioid peptides (leu and met-enkephalin) discovered in 1975.
  • Opioid systems' physiological and pathophysiological roles are under extensive investigation.

Purpose of the Study:

  • To review recent findings on the link between endogenous opioid peptides and epilepsy.
  • To elucidate the function of opioid systems in epilepsy.

Main Methods:

  • Literature review of recent studies.
  • Synthesis of current understanding on opioid peptides and epilepsy.

Main Results:

  • Current understanding of opioid peptides in epilepsy is fragmented.
  • Evidence suggests a significant role for endogenous opioid peptides in epilepsy.

Conclusions:

  • Further research is fundamental to fully understand opioid function in epilepsy.
  • Endogenous opioid peptides represent a promising area for epilepsy pharmacotherapy.

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