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Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Standardization versus individualization: how each contributes to managing dose in computed tomography.

Cynthia H McCollough1

  • 1*Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

Health Physics
|October 1, 2013
PubMed
Summary

Optimizing computed tomography (CT) radiation doses requires tailoring parameters to individual patients and diagnostic needs. Medical professionals must minimize dose variations unrelated to patient size or task for safe and effective imaging.

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Area of Science:

  • Medical Imaging
  • Radiology
  • Radiation Dose Management

Background:

  • Computed tomography (CT) dose management is crucial for patient safety.
  • Variability in CT doses is observed due to diverse patient populations and diagnostic tasks.

Purpose of the Study:

  • To emphasize the importance of appropriate dose variation in medical imaging.
  • To highlight the need for minimizing unacceptable dose variations in CT scans.

Main Methods:

  • Analysis of dose variation in computed tomography (CT).
  • Focus on patient-specific and task-specific scan parameter optimization.

Main Results:

  • A significant portion of CT dose variation is appropriate and necessary.
  • Unacceptable sources of dose variation also exist and require mitigation.

Conclusions:

  • Medical imaging professionals are responsible for optimizing CT scan parameters.
  • Scan parameters should be tailored to both patient size and the specific diagnostic task to ensure appropriate dose management.