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08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
New targeted therapies in melanoma
Ragini R Kudchadkar1, Rene Gonzalez, Karl Lewis
1Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA. Ragini.Kudchadkar@Moffitt.org.
Cancer Control : Journal of the Moffitt Cancer Center
|October 1, 2013
Summary
Recent advances in melanoma treatment, including targeted therapies like vemurafenib and immune modulators such as ipilimumab, have improved survival for advanced melanoma patients. Ongoing research focuses on novel agents and combination therapies to address treatment resistance and identify new molecular targets.
Area of Science:
- Oncology
- Dermatology
- Immunology
Background:
- Recent years have seen significant advancements in melanoma research, marked by the approval of targeted therapies like vemurafenib and immune checkpoint inhibitors like ipilimumab for advanced stages.
- Growing understanding of melanoma's molecular biology has spurred the development of novel agents targeting specific oncogenes driving tumor growth.
Purpose of the Study:
- To review the latest developments in signal transduction inhibitors and immune modulators for melanoma treatment.
- To discuss investigational agents currently under development for melanoma therapy.
Main Methods:
- Literature review of recent advancements in melanoma treatment modalities.
- Analysis of clinical trial data and research on novel therapeutic agents.
Main Results:
- Vemurafenib and ipilimumab have demonstrated improved overall survival in patients with metastatic melanoma.
- Numerous novel agents, including programmed death-1 (PD-1) antibodies and combination signal transduction inhibitors, are in development.
Conclusions:
- Advances in understanding melanoma's genetic diversity and the immune system have led to improved survival rates for metastatic melanoma patients.
- Refractory melanoma cases present ongoing challenges, prompting exploration of combination therapies to overcome resistance mechanisms.
- Identification of new molecular targets is crucial for treating patients with BRAF wild-type melanoma.
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