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Vitamin D and long-term memory in multiple sclerosis.

Nancy S Koven¹, Margaret H Cadden, Sangita Murali

¹*Program of Neuroscience, Bates College, Lewiston, ME †Central Maine Medical Center Neurology, Auburn, ME.

Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology

|October 1, 2013

Summary

This summary is machine-generated.

Higher vitamin D levels are linked to better nonverbal long-term memory in multiple sclerosis (MS) patients. This suggests vitamin D may be a beneficial addition to MS treatment, supporting cognitive function.

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Area of Science:

Neuroscience
Immunology
Endocrinology

Background:

Memory disturbances are common in multiple sclerosis (MS).
Emerging research indicates vitamin D may play a role in memory functions.
The impact of vitamin D on cognitive impairments in MS remains unclear.

Purpose of the Study:

To investigate the association between serum vitamin D levels and long-term memory performance in individuals with MS.
To explore if vitamin D influences verbal and nonverbal memory recall under varying retrieval demands.

Main Methods:

35 adults with relapsing-remitting MS underwent cognitive testing and serum 25-hydroxyvitamin D [25(OH)D] assays.
Neuropsychological tests assessed memory performance, including immediate and delayed recall.
Intelligence and mood were evaluated as potential confounding factors.

Main Results:

Serum vitamin D levels positively correlated with performance on nonverbal memory tasks (Rey Complex Figure Test), even after adjusting for intelligence and disease duration.
No significant association was found between vitamin D levels and verbal memory performance (California Verbal Learning Test, Second Edition).
Vitamin D levels were not linked to mood or intelligence in the study cohort.

Conclusions:

Elevated vitamin D levels are associated with enhanced nonverbal long-term memory in MS patients.
This effect was particularly notable when memory retrieval did not involve external aids.
The findings support vitamin D's potential neuroprotective role and suggest its utility as an adjunctive therapy for MS.