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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Autonomic Nervous System01:22

Autonomic Nervous System

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Autonomic Nervous System: Overview01:26

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

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Updated: May 7, 2026

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Autonomic nerve development contributes to prostate cancer progression.

John Bauman, Kevin McVary

    Asian Journal of Andrology
    |October 1, 2013
    PubMed
    Summary

    The autonomic nervous system influences prostate cancer. The sympathetic system aids early tumor growth, while the parasympathetic system promotes cancer spread, offering new therapeutic targets.

    Area of Science:

    • Translational oncology
    • Autonomic nervous system research
    • Prostate cancer biology

    Background:

    • The autonomic nervous system (ANS) regulates involuntary bodily functions.
    • Its role in cancer development and progression is an emerging area of research.
    • Prostate cancer remains a significant global health concern.

    Purpose of the Study:

    • To investigate the specific roles of the sympathetic and parasympathetic nervous systems in prostate cancer.
    • To elucidate the mechanisms by which the ANS influences tumorigenesis and cancer dissemination.
    • To identify potential therapeutic targets within the ANS for prostate cancer management.

    Main Methods:

    • Utilized a translational study design involving both murine (mouse) models and human prostate cancer samples.

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  • Employed techniques to differentiate and assess the activity of sympathetic and parasympathetic nervous system components.
  • Analyzed the impact of ANS activity on key prostate cancer progression markers.

    • Main Results:

    • The sympathetic nervous system was found to promote early-stage prostate cancer development (tumorigenesis).
    • The parasympathetic nervous system was identified as a promoter of prostate cancer cell dissemination and metastasis.
    • Demonstrated distinct and opposing roles for the two major ANS branches in prostate cancer progression.

    Conclusions:

    • The autonomic nervous system plays a critical, dichotomous role in prostate cancer.
    • Targeting specific ANS branches could offer novel strategies for treating and managing prostate cancer.
    • Findings provide a foundation for developing new therapies aimed at modulating the ANS to inhibit cancer growth and spread.