Related Experiment Video
Updated: May 7, 2026

Listeria monocytogenes Infection of the Brain
Published on: October 2, 2018
[A case of spontaneous bacterial peritonitis caused by Listeria monocytogenes]
Byung Sihk Kim1, Tae Yeob Kim, Ji Yeoun Kim
1Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
Abstract:
Spontaneous bacterial peritonitis (SBP) is a life-threatening complication in patients with ascites caused by advanced liver disease. While gram negative bacteria, such as Escherichia coli and Klebsiella pneumonia are the common pathogens, Listeria monocytogenes has been recognized as a very rare pathogen. Empirical treatment with third generation cephalosporins does not provide adequate antibiotics coverage against L. monocytogenes. Diagnosis is often delayed as it requires confirmation from ascitic fluid culture. Herein, we describe the first case of SBP caused by L. monocytogenes in a patient with advanced alcoholic liver cirrhosis in Korea. Clinicians should be aware of the atypical pathogens, especially in patients with inadequate response to empirical antibiotics.
Insights
Spontaneous bacterial peritonitis (SBP) is a serious liver disease complication. This case highlights Listeria monocytogenes as a rare SBP cause, requiring awareness for effective treatment.
Area of Science:
- Hepatology
- Infectious Diseases
- Microbiology
Background:
- Spontaneous bacterial peritonitis (SBP) is a severe complication in patients with advanced liver disease and ascites.
- Commonly caused by Gram-negative bacteria like E. coli, SBP necessitates prompt antibiotic treatment.
- Listeria monocytogenes is a rare but significant pathogen in SBP cases.
Observation:
- This report details the first case of SBP caused by Listeria monocytogenes in Korea.
- The patient had advanced alcoholic liver cirrhosis.
- Diagnosis was confirmed through ascitic fluid culture.
Findings:
- Empirical treatment with third-generation cephalosporins is inadequate against Listeria monocytogenes.
- Delayed diagnosis is common due to the need for microbiological confirmation.
- Listeria monocytogenes represents an atypical pathogen in SBP.
Implications:
- Clinicians must consider atypical pathogens like Listeria monocytogenes in SBP cases.
- Inadequate response to empirical antibiotics warrants investigation for unusual causative agents.
- Increased awareness of Listeria monocytogenes in SBP can improve patient outcomes.
Related Concept Videos
Reservoir of Infection
Bacterial Gastroenteritis
Bacterial Meningitis I: Introduction
Bacterial Phylum Spirochaetes
Atypical Pneumonia
Bacterial Meningitis II: Pathophysiology

