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Related Concept Videos

Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
Autocrine Signaling01:01

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...

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Related Experiment Video

Updated: May 7, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

MaxiK channel and cell signalling.

Ligia Toro, Min Li, Zhu Zhang

    Pflugers Archiv : European Journal of Physiology
    |October 1, 2013
    PubMed
    Summary
    This summary is machine-generated.

    The large-conductance Ca2+- and voltage-activated K+ (MaxiK) channel interacts with numerous proteins and G protein-coupled receptors, influencing cell signaling, metabolism, and disease. Understanding these interactions may lead to new cancer therapies.

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    Dissection of Local Ca2+ Signals in Cultured Cells by Membrane-targeted Ca2+ Indicators

    Published on: March 22, 2019

    Area of Science:

    • Cellular Biology
    • Molecular Biology
    • Physiology

    Background:

    • The large-conductance Ca2+- and voltage-activated K+ (MaxiK) channel is increasingly recognized for its role in cellular signaling.
    • Interactions extend beyond the plasma membrane to intracellular organelles like the ER, nucleus, and mitochondria.

    Purpose of the Study:

    • To review the interactions of MaxiK channels with seven-transmembrane G protein-coupled receptors.
    • To explore the MaxiK channel's C-terminus as a signaling hub for cell death and survival pathways.
    • To highlight the diverse functions and implications of MaxiK channels in various physiological and pathological processes.

    Main Methods:

    • Literature review focusing on MaxiK channel interactions with G protein-coupled receptors.
    • Analysis of existing evidence on MaxiK channel associations with various receptors (e.g., adrenergic, estrogen, acetylcholine, thromboxane A2, angiotensin II).
    • Examination of MaxiK channel's involvement in cell metabolism, proliferation, migration, gene expression, and disease states.

    Main Results:

    • MaxiK channels associate with multiple G protein-coupled receptors, including β-adrenergic, G protein-coupled estrogen, acetylcholine, thromboxane A2, and angiotensin II receptors.
    • The channel's C-terminus may serve as a scaffold for signaling molecules, including kinases involved in cell death and survival.
    • MaxiK channels are implicated in diverse functions such as muscle contraction, neurotransmission, cell metabolism, proliferation, migration, and gene expression.

    Conclusions:

    • MaxiK channel interactions with G protein-coupled receptors underscore its broad functional significance.
    • Abnormalities in MaxiK channel expression, particularly overexpression in cancers, suggest potential therapeutic targets.
    • Further understanding of MaxiK channel molecular mechanisms could pave the way for novel treatments for diseases like obesity and various cancers.