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Updated: May 7, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Taste performance in Parkinson’s disease.

Maria Paola Cecchini, Francesco Osculati, Sarah Ottaviani

Journal of Neural Transmission (Vienna, Austria : 1996)

|October 1, 2013

Summary

This summary is machine-generated.

Parkinson's disease (PD) patients show reduced taste perception, particularly with the Taste Strip Test (TST), while olfactory deficits are confirmed. Whole Mouth Testing (WMT) did not reveal taste impairment in early-stage PD.

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Olfactory Assays for Mouse Models of Neurodegenerative Disease

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Published on: August 25, 2014

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Last Updated: May 7, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

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Olfactory Assays for Mouse Models of Neurodegenerative Disease

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

Area of Science:

Neuroscience
Sensory Science
Clinical Neurology

Background:

Olfactory dysfunction is a known early symptom of Parkinson's disease (PD).
Taste perception alterations in PD are not fully understood.
Early diagnosis and understanding of sensory deficits in PD are crucial for patient management.

Purpose of the Study:

To investigate and compare taste perception in patients with Parkinson's disease (PD) and healthy controls (HC).
To evaluate olfactory function in PD patients using standardized tests.
To explore potential discrepancies in taste testing methods and their implications for PD.

Main Methods:

Utilized the Whole Mouth Taste Test (WMT) and Taste Strip Test (TST) to assess gustatory function in 61 PD patients and 66 HC.
Employed the Sniffin' Sticks Test (SST) to evaluate olfactory performance.
Statistical analysis to compare test scores between PD patients and HC.

Main Results:

PD patients exhibited significantly lower scores on the Taste Strip Test (TST) compared to HC (p<0.018).
No significant difference in taste perception was found between PD patients and HC using the Whole Mouth Test (WMT).
Confirmed significant olfactory deficits in PD patients, with lower Sniffin' Sticks Test (SST) scores than HC (p<0.0001).

Conclusions:

Taste impairment in early-stage Parkinson's disease may be detectable with specific methods like TST, but not WMT.
The findings suggest taste alterations in PD might occur at concentrations below those typically used in WMT.
Further research into the biological basis of gustatory dysfunction in PD is warranted.