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Tumor progression and transformation of low-grade glial tumors associated with pregnancy

Mariza Daras, Christina Cone, Katherine B Peters

    Journal of Neuro-Oncology
    |October 1, 2013
    PubMed

    Brain tumor growth or progression has been shown to occur in low-grade glial tumors and meningiomas. While progression has been documented in this population, transformation to a more aggressive high-grade glial tumor that can lead to increased morbidity and mortality has not been identified. In this case series, we document transformation from low-grade gliomas to high-grade gliomas (WHO grade III and IV) in young women during pregnancy. We further discuss the possible etiologies of this phenomenon.

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