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Updated: May 7, 2026
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Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
Published on: July 11, 2016
Rothia aeria mitral valve endocarditis complicated by multiple mycotic aneurysms: laboratory identification
Infection
|October 1, 2013
Summary
Rothia aeria, rarely a human pathogen, caused severe heart valve infection and multiple aneurysms. Early identification was key using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS).
Area of Science:
- Infectious Diseases
- Cardiology
- Neurology
Background:
- Rothia aeria is infrequently recognized as a human pathogen.
- Infective endocarditis and mycotic aneurysms are serious conditions requiring prompt diagnosis and treatment.
Observation:
- This report details a rare case of Rothia aeria infection.
- The infection manifested as mitral valve endocarditis and multiple mycotic aneurysms, including those in the brain.
Findings:
- Rothia aeria was successfully identified as the causative agent.
- Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) enabled early and accurate diagnosis.
Implications:
- This case highlights the potential pathogenicity of Rothia aeria.
- MALDI-TOF MS is a valuable tool for rapid identification of unusual pathogens in critical infections.
- Early diagnosis and treatment are crucial for managing complex infections like endocarditis and mycotic aneurysms.
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