Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Pharmacokinetic–Pharmacodynamic Relationship: Problems01:24

Pharmacokinetic–Pharmacodynamic Relationship: Problems

The empirical approach to drug therapy optimization relies on correlating pharmacological response with administered dosage. Such an approach can be costly, time-consuming, and often yields poor correlation due to variables like formulation factors and drug elimination characteristics. A more precise approach correlates response with plasma drug concentration or the amount of drug in the body, rather than dosage. This is achieved through pharmacokinetic-pharmacodynamic (PK/PD) modeling, which...
Measurement of Bioavailability: Pharmacodynamic Methods01:20

Measurement of Bioavailability: Pharmacodynamic Methods

Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Health check-up of a freshwater bivalve exposed to lithium.

Environmental pollution (Barking, Essex : 1987)·2024
Same author

Clinical guide to perioperative management for videothoracoscopy lung resection (Section of Cardiac, Vascular and Thoracic Anesthesia, SEDAR; Spanish Society of Thoracic Surgery, SECT; Spanish Society of Physiotherapy).

Revista espanola de anestesiologia y reanimacion·2022
Same author

Clinical guide to perioperative management for videothoracoscopy lung resection (Section of Cardiac, Vascular and Thoracic Anesthesia, SEDAR; Spanish Society of Thoracic Surgery, SECT; Spanish Society of Physiotherapy).

Revista espanola de anestesiologia y reanimacion·2021
Same author

Molecular response of a sub-antarctic population of the blue mussel (Mytilus edulis platensis) to a moderate thermal stress.

Marine environmental research·2021
Same author

Cytotoxicity and genotoxicity of lanthanides for Vicia faba L. are mediated by their chemical speciation in different exposure media.

The Science of the total environment·2021
Same author

Assessment of the toxic effects of mixtures of three lanthanides (Ce, Gd, Lu) to aquatic biota.

The Science of the total environment·2019

Related Experiment Video

Updated: May 7, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

The integrated biomarker response revisited: optimization to avoid misuse.

S Devin, T Burgeot, L Giambérini

    Environmental Science and Pollution Research International
    |October 1, 2013
    PubMed
    Summary

    This study introduces a new, reliable method for calculating the Integrated Biomarker Response (IBR) to assess aquatic ecosystem health. The improved approach corrects biases and simplifies interpretation for environmental policy integration.

    Related Experiment Videos

    Last Updated: May 7, 2026

    Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
    07:35

    Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

    Published on: October 11, 2018

    Area of Science:

    • Environmental Science
    • Ecotoxicology
    • Biomonitoring

    Background:

    • Evaluating aquatic ecosystem quality necessitates effective monitoring tools.
    • Biomarker-based approaches offer precocity and relevance but face interpretation challenges.
    • Existing integrative indices, like the Integrated Biomarker Response (IBR), suffer from misuse and calculation bias.

    Purpose of the Study:

    • To address the limitations of current multi-biomarker interpretation in environmental policy.
    • To propose a novel, robust calculation method for the Integrated Biomarker Response (IBR).
    • To ensure accurate and unbiased assessment of aquatic ecosystem health using biomarkers.

    Main Methods:

    • Development of a new, simplified formula for IBR calculation.
    • Implementation of a permutation procedure to mitigate bias.
    • Application of the revised IBR method in a case study involving pollution gradient classification.

    Main Results:

    • The new IBR calculation method effectively avoids misuse and bias.
    • The revised procedure allows for reliable classification of sites along a pollution gradient.
    • Biomarker responses were successfully integrated for environmental assessment.

    Conclusions:

    • The proposed IBR calculation method enhances the reliability of aquatic ecosystem quality assessment.
    • This advancement facilitates the integration of biomarker data into environmental policies.
    • The improved IBR provides a more accurate tool for biomonitoring and pollution assessment.