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Updated: May 7, 2026

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
Published on: February 25, 2016
Nitric oxide, S-nitrosation, and endothelial permeability
Walter N Durán1, Annie V Beuve, Fabiola A Sánchez
1Department of Pharmacology and Physiology, New Jersey Medical School; Rutgers, The State University of New Jersey, Newark, NJ, 07101-1709, U.S.A.
Abstract:
S-Nitrosation is rapidly emerging as a regulatory mechanism in vascular biology, with particular importance in the onset of hyperpermeability induced by pro-inflammatory agents. This review focuses on the role of endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) in regulating S-Nitrosation of adherens junction proteins. We discuss evidence for translocation of eNOS, via caveolae, to the cytosol and analyze the significance of eNOS location for S-Nitrosation and onset of endothelial hyperpermeability to macromolecules.
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