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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.

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Related Experiment Video

Updated: May 7, 2026

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

The bone anabolic therapy.

A Nardi, L Ventura, L Cozzi

    Aging Clinical and Experimental Research
    |October 1, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Teriparatide (TPTD) strengthens bone, preventing fractures in osteoporosis patients. Its proven safety and anabolic effects are now being explored for other bone conditions like delayed healing.

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    Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
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    Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

    Published on: April 14, 2016

    Related Experiment Videos

    Last Updated: May 7, 2026

    Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
    11:20

    Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

    Published on: March 29, 2018

    Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
    07:17

    Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

    Published on: April 14, 2016

    Area of Science:

    • Bone Biology and Pharmacology
    • Osteoporosis Treatment
    • Fracture Healing Research

    Background:

    • Teriparatide (TPTD), a recombinant parathyroid hormone peptide (PTH 1–34), exhibits proven bone anabolic action.
    • TPTD is FDA-approved for osteoporosis, effectively preventing vertebral and non-vertebral fragility fractures.
    • Extensive research details TPTD's positive impact on cortical bone strength, particularly in the hip region.

    Purpose of the Study:

    • To review the established efficacy and safety of Teriparatide (TPTD) in osteoporosis.
    • To explore emerging applications of TPTD beyond osteoporosis treatment.
    • To highlight the potential for expanded clinical use based on preliminary findings.

    Main Methods:

    • Literature review of TPTD's effects on bone structure and fracture prevention.
    • Analysis of clinical data regarding TPTD's safety profile and patient usage.
    • Examination of recent publications on TPTD's application in conditions beyond osteoporosis.

    Main Results:

    • TPTD demonstrates significant anabolic effects, enhancing bone strength and reducing fracture risk.
    • Over one million patients have been treated worldwide with a consistent safety profile.
    • Emerging studies suggest TPTD's potential utility in delayed fracture healing, non-union, and osteonecrosis of the jaw.

    Conclusions:

    • Teriparatide (TPTD) is a well-established anabolic agent for osteoporosis with a favorable safety record.
    • Preliminary evidence suggests TPTD may offer therapeutic benefits for various bone-related conditions.
    • Further clinical investigation is warranted to confirm these novel applications and expand TPTD's therapeutic scope.