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Published on: October 2, 2016
Diterpenoids from Acanthopanax brachypus Harms
Hao-Bin Hu1, Xu-Dong Zheng, Huai-Sheng Hu
1College of Chemistry & Chemical Engineering, Longdong University, Qingyang 745000, P. R. China, (phone: +86-934-8658532; fax: +86-934-8651531). hhb-88@126.com.
Abstract:
Four diterpenoids, including two new ones, namely noracanthopanin A (1) and acanthopanolide B (2), and two known ones, ent-pimara-9(11),15-dien-19-oic acid (3) and ent-kaur-16-en-19-oic acid (4), were isolated from the stem bark of Acanthopanax brachypus Harms. Their structures were elucidated by physicochemical and spectroscopic analyses. Compound 1 and 2 exhibited moderate cytotoxicities against HO-8910 cells with IC50 values of 65.21±0.23 and 31.43±1.01 μg/ml, respectively, and 2 showed selective weak cytotoxicity against SMMC-7721 cells (IC50 89.67±2.54 μg/ml).
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