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Updated: May 7, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
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Published on: March 21, 2013

Postexercise syncope: Wingate syncope test and effective countermeasure.

Alisha N Lacewell1, Tahisha M Buck, Steven A Romero

  • 1J. R. Halliwill: 122 Esslinger Hall, 1240 University of Oregon, Eugene, OR 97403-1240, USA. halliwil@uoregon.edu.

Experimental Physiology
|October 1, 2013
PubMed
Summary
This summary is machine-generated.

A modified Wingate exercise test can induce post-exercise syncope. Breathing through an impedance threshold device improved tolerance to head-up tilt, preventing syncope in healthy individuals.

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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Area of Science:

  • Exercise Physiology
  • Cardiovascular Physiology
  • Autonomic Neuroscience

Background:

  • Altered systemic hemodynamics after exercise can impair cerebral blood flow, leading to syncope.
  • The Wingate anaerobic test frequently causes presyncope, suggesting its potential for studying post-exercise syncope.
  • Breathing via an impedance threshold device can enhance tolerance to low blood volume (hypovolemia).

Purpose of the Study:

  • To establish a novel model for studying post-exercise syncope using a modified Wingate test.
  • To investigate the efficacy of an impedance threshold device as a countermeasure against post-exercise syncope.
  • To assess the impact of the countermeasure on hemodynamic and cerebral oxygenation parameters during head-up tilt.

Main Methods:

  • Nineteen healthy participants (men and women) underwent a modified Wingate test followed by 60-degree head-up tilt.
  • Measurements included arterial pressure, heart rate, end-tidal CO2, and cerebral tissue oxygenation.
  • Participants were tested on two conditions: a control day and a countermeasure day using an impedance threshold device.

Main Results:

  • The duration of tolerable head-up tilt significantly increased by a median of 3 minutes and 48 seconds with the impedance threshold device (P < 0.05).
  • Successful completion of the tilt test improved from 42% in the control condition to 67% with the countermeasure.
  • Mean arterial pressure during tilt was significantly higher with the countermeasure (108.0 ± 4.1 mmHg) compared to the control (100.4 ± 2.4 mmHg).

Conclusions:

  • A modified Wingate test combined with head-up tilt effectively models post-exercise syncope and presyncope.
  • Breathing through an impedance threshold device serves as an effective countermeasure, increasing syncope tolerance and hemodynamic stability.
  • Inspiratory impedance demonstrates potential as a countermeasure for conditions involving post-exercise hypotension and syncope.