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Published on: June 28, 2018
STAR: an integrated solution to management and visualization of sequencing data.
1Department of Chemistry and Biochemistry, University of California, San Diego, CA 92093, USA, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, The ARC Centre of Excellence in Plant Energy Biology, The University of Western Australia, Crawley, Western Australia 6009, Australia, Key Laboratory for Symbolic Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, Changchun 130012, China, Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA, Department of Cellular and Molecular Medicine, University of California, San Diego, CA 92093, USA and Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA.
STAR is a web application for visualizing and analyzing complex next-generation sequencing (NGS) data. It offers an integrated platform for online data management and track-based analysis, simplifying NGS data exploration.
Area of Science:
- Bioinformatics
- Computational Biology
- Genomics
Background:
- Effective visualization of complex data is crucial for next-generation sequencing (NGS) studies.
- Existing tools may not adequately address the need for integrated management and analysis of NGS data.
Purpose of the Study:
- To develop an integrated web application for online management, visualization, and track-based analysis of NGS data.
- To provide a user-friendly platform for exploring complex genomic datasets.
Main Methods:
- Developed STAR, a multilayer web service system.
- Utilized JavaScript, HTML5 Canvas, and asynchronous communications for a dynamic client-side interface.
- Implemented server-side account management for session state retention and data management modules.
Main Results:
- STAR provides a desktop-like graphical user interface with in-browser analysis tools.
- The system supports collection, visualization, and analysis of third-party sequencing data.
- Hosts thousands of data tracks, enabling sophisticated feature detection and data exploration.
Conclusions:
- STAR offers a next-generation solution for NGS data exploration.
- Enables intuitive visualization and dynamic analysis of complex genomic datasets.
- Facilitates efficient management and analysis of diverse sequencing data.
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