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08:26
Assessing Activity-based Anorexia in Mice
Published on: May 14, 2018
Anorexia nervosa, obesity and bone metabolism
Madhusmita Misra1, Anne Klibanski
1Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. mmisra@partners.org
Pediatric Endocrinology Reviews : PER
|October 2, 2013
Summary
Anorexia nervosa and obesity increase fracture risk by affecting bone density and structure. Adipose tissue distribution and related hormones play a key role in bone metabolism for both conditions.
Area of Science:
- Nutritional Science
- Bone Metabolism
- Endocrinology
Background:
- Anorexia nervosa and obesity represent extreme variations in body fat content.
- Both conditions are linked to an elevated risk of fractures.
- Bone health is significantly impacted in individuals with anorexia nervosa and obesity.
Purpose of the Study:
- To review bone metabolism in anorexia nervosa and obesity.
- To explore the relationship between adipose tissue distribution and bone health.
- To examine the role of hormones regulated by body fat in bone density and structure.
Main Methods:
- Literature review of studies on anorexia nervosa, obesity, bone metabolism, and adipose tissue.
- Analysis of the impact of body composition on bone density and strength.
- Investigation of hormonal influences on bone health in relation to body fat.
Main Results:
- Anorexia nervosa is associated with low bone density, impaired bone structure, and reduced bone strength, influenced by body composition and hormones.
- Increased marrow adiposity and decreased brown adipose tissue in anorexia nervosa correlate with low bone density.
- Obesity, particularly visceral adiposity, is linked to increased marrow fat, lower bone density, and impaired bone structure.
Conclusions:
- Adipose tissue distribution and associated hormones are critical factors in bone metabolism for both anorexia nervosa and obesity.
- Understanding these relationships is crucial for addressing fracture risk in these populations.
- Further research into targeted interventions based on adipose tissue characteristics may improve bone health outcomes.
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