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A concise and efficient total synthesis of α-mangostin and β-mangostin from Garcinia mangostana
Dandan Xu1, Ying Nie, Xizhou Liang
1Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
Natural Product Communications
|October 2, 2013
Abstract:
The concise, efficient synthesis of alpha-mangostin is described in eight simple steps with 8.3% overall yield. Highlights include a practical approach to construct the isopentene groups and other diverse groups at C-2 and C-8 of the xanthene skeleton through Claisen rearrangement and Wittig reaction. Meanwhile the first total synthesis of beta-mangostin is presented with a similar approach.
