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A new cytotoxic phenolic derivative from the roots of Antidesma acidum
Sutin Kaennakam1, Jirapast Sichaem, Pongpun Siripong
1Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Abstract:
A new phenolic derivative, acidumonate (1), together with a synthetically known compound, 4-((E)-3,3-dimethylpenta-1,4-dienyl)-phenol (2), and sixteen known natural products, antidesmol (3), mellein (4), sitosterol (5), stigmasterol (6), 5-cholesten-3beta-ol (7), 4-cholesten-3-one (8), 3-(1,1-dimethylallyl)-scopoletin (9), (-)- 5,7-dihydroxy-2-eicosyl-chromone (10), 2,5-dimethoxy-1,4-benzoquinone (11), barbatumol A (12), N-trans-feruloyltyramine (13), syringic aldehyde (14), p-hydroxybenzoic acid (15), taxifolin (16), (+)-catechin (17) and gallocatechin (18), were isolated from the roots of Antidesma acidum. The structural assignment of the new compound was based on spectroscopic methods. All isolated compounds were evaluated for their cytotoxicity (KB and HeLa cells). Compound 1 showed good cytotoxicity against both cell lines (with IC50 values of 2.60 and 3.80 microg/mL, respectively).
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