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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Chronic Obstructive Pulmonary Disease01:24

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Effect of thyroid function on COPD exacerbation frequency: a preliminary study.

Sevinc Sarinc Ulasli1, Serife Savas Bozbas, Zeynep Erayman Ozen

  • 1Medical Faculty, Department of Pulmonary Diseases, Afyon Kocatepe University, Afyon, Turkey. sevincsarinc@gmail.com.

Multidisciplinary Respiratory Medicine
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Hypothyroidism in chronic obstructive pulmonary disease (COPD) patients is linked to increased exacerbations and lower quality of life. Early thyroid function screening can improve COPD management and patient well-being.

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Published on: August 24, 2019

Area of Science:

  • Pulmonary Medicine
  • Endocrinology

Background:

  • Frequent exacerbations significantly impair quality of life and survival in COPD patients.
  • Identifying factors influencing COPD exacerbations is crucial for effective management.
  • Thyroid function's impact on COPD exacerbations and quality of life requires further investigation.

Purpose of the Study:

  • To evaluate the effect of thyroid function, specifically hypothyroidism, on exacerbation frequency in COPD patients.
  • To assess the relationship between thyroid function and quality of life in individuals with COPD.
  • To compare pulmonary function and respiratory muscle strength between COPD patients with and without hypothyroidism.

Main Methods:

  • A cohort of 128 participants, including COPD patients with hypothyroidism (n=44), COPD patients with normal thyroid function (n=44), and healthy controls (n=40), was studied.
  • Pulmonary function tests (FVC, FEV1/FVC, FEF 25-75%), maximum inspiratory/expiratory pressures (MIP/MEP), and the SF-36 quality of life questionnaire were administered.
  • Patients were monitored for one year to record the frequency of exacerbations.

Main Results:

  • COPD patients with hypothyroidism exhibited significantly poorer pulmonary function (FVC, FEV1/FVC, FEF 25-75%) and maximal expiratory pressure (MEP) compared to those with normal thyroid function.
  • Quality of life scores were significantly lower in both COPD groups compared to healthy controls, with hypothyroidism group showing lower scores.
  • A positive correlation was found between TSH levels and exacerbation frequency (r=0.82), with hypothyroid COPD patients experiencing more exacerbations (p=0.017).

Conclusions:

  • Thyroid function, particularly hypothyroidism, significantly influences exacerbation frequency in COPD patients.
  • Early detection and management of thyroid dysfunction in COPD patients can lead to reduced exacerbations.
  • Improving thyroid function in COPD patients is expected to positively impact their quality of life and potentially survival outcomes.