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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.

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Related Experiment Video

Updated: May 7, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

PINTing for p53.

Ramin Shiekhattar

    Genome Biology
    |October 2, 2013
    PubMed
    Summary
    This summary is machine-generated.

    A new study reveals that the long noncoding RNA Pintas regulates cell growth. Pintas is also identified as a key target within the p53 signaling pathway.

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    Published on: September 10, 2017

    Area of Science:

    • Molecular Biology
    • Genetics
    • Cancer Research

    Background:

    • Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in gene regulation.
    • The p53 pathway is a critical tumor suppressor network involved in cellular responses to stress.

    Purpose of the Study:

    • To investigate the function of the novel long noncoding RNA Pintas.
    • To determine the relationship between Pintas and the p53 signaling pathway.

    Main Methods:

    • Gene expression analysis
    • Cellular proliferation assays
    • p53 pathway activity assessment

    Main Results:

    • Pintas was identified as a regulator of cellular proliferation.
    • Pintas was shown to be a direct or indirect target of the p53 pathway.

    Conclusions:

    • The lncRNA Pintas plays a significant role in controlling cell growth.
    • Pintas represents a potential link between lncRNA function and p53-mediated tumor suppression.