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Updated: May 7, 2026

Production of Human Norovirus Protruding Domains in E. coli for X-ray Crystallography
Published on: April 19, 2016
Novel intergenotype human norovirus recombinant GII.16/GII.3 in Bangladesh
Shamsun Nahar1, Mokibul Hassan Afrad, Jelle Matthijnssens
1Department of Microbiology, Jahangirnagar University, Savar, Dhaka, Bangladesh.
Abstract:
Noroviruses (NoVs) are one of the major etiological agents of acute gastroenteritis in all age groups. In this study, we identified an intergenotype NoV recombinant strain in the fecal specimens of two male infants with acute diarrhea in Bangladesh. Phylogenetic analysis showed that the identified strains were recombinant NoV strains with a GII.3 capsid and a GII.16 polymerase gene. The recombination breakpoint was located in the ORF1/ORF2 overlap region. To the best of our knowledge this is the first report of a NoV recombinant GII.16/GII.3 strain worldwide.

