Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

B cells in thymomas.

M J Kornstein1, S Kay

  • 1Department of Pathology, Medical College of Virginia, Richmond.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TRICHINELLA MURRELLI POZIO AND LA ROSA, 2000 IN A GRAY FOX (UROCYON CINEREOARGENTEUS) FROM PENNSYLVANIA: A NEW HOST RECORD FOR THIS ZOONOTIC NEMATODE.

The Journal of parasitology·2024
Same author

Agroecology landscapes.

Landscape ecology·2021
Same author

Helicity-Dependent Cross Sections for the Photoproduction of π^{0} Pairs from Nucleons.

Physical review letters·2020
Same author

Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis.

Osteoarthritis and cartilage·2020
Same author

Does as Little as Two Hours a Day of Television Viewing Increase the Risk of Young-Onset Colorectal Cancer?

JNCI cancer spectrum·2019
Same author

Study of η and η' Photoproduction at MAMI.

Physical review letters·2017
Same journal

Expanding the Spectrum of High-Risk Human Papilloma Virus (HPV)-Associated Glandular Neoplasms of the Anorectum.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026
Same journal

Deep Learning for Differentiating Pulmonary Metastasis from Primary Lung Cancer Constructed on Frozen Sections for Intraoperative Diagnosis.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026
Same journal

Margin Adequacy in Phyllodes Tumours Revisited: Reappraisal of the Evidence Base and Knowledge Gaps.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026
Same journal

Genomic Characterization of Classic Adamantinoma, Osteofibrous Dysplasia, and Osteofibrous Dysplasia-like Adamantinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026
Same journal

Immunophenotypic, Cytogenetic, and Molecular Characterization of NUP98-Rearranged Pediatric Myeloid Neoplasms.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026
Same journal

Chromoanagenesis in Myelodysplastic Syndromes Is Associated With Highly Complex Karyotype, TP53 Disruption and Dismal Prognosis.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026
See all related articles

This study found B cells and germinal centers in some thymomas, challenging previous assumptions. These findings are important for understanding thymic tumors and their associations.

Area of Science:

  • Immunology
  • Oncology
  • Pathology

Background:

  • Previous research identified thymoma-associated lymphocytes primarily as T cells.
  • Thymomas are neoplasms of the thymus gland, often associated with autoimmune conditions.

Purpose of the Study:

  • To investigate the presence and significance of germinal centers (GC) and B cells within thymomas.
  • To determine the association of germinal centers in thymomas with myasthenia gravis (MG) and adjacent thymic tissue.

Main Methods:

  • Histopathological examination of six thymoma samples.
  • Immunoperoxidase staining using antibodies LN1, LN2, and L26 to identify B cells.

Main Results:

  • Six thymomas exhibited germinal centers (GC) within the tumor capsule.

Related Experiment Videos

  • Three mixed lymphocytic-epithelial thymomas had interspersed GC, unrelated to MG or adjacent thymus.
  • Three lymphocytic thymomas showed subcapsular GC, occurring in MG patients and associated with GC in adjacent thymus.
  • Immunoperoxidase studies confirmed the presence of B cells in thymomas, especially those with GC.

    • Conclusions:

    • The presence of B cells and germinal centers in certain thymomas is confirmed.
    • Germinal centers in thymomas are not exclusively linked to myasthenia gravis.
    • These findings necessitate consideration of B cells in thymomas for research on Epstein-Barr virus association with thymic tumors.