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Related Experiment Video

Updated: May 7, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

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Published on: June 2, 2014

Acral coldness in migraineurs.

Nina Zaproudina1, Jukka A Lipponen2, Pasi A Karjalainen2

  • 1Institute of Biomedicine, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland; Institute of Dentistry, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland.

Autonomic Neuroscience : Basic & Clinical
|October 2, 2013
PubMed
Summary
This summary is machine-generated.

Migraine patients exhibit colder facial and hand skin temperatures compared to healthy individuals, suggesting abnormal autonomic vascular control. This peripheral coldness, particularly in the nose and hands, may serve as a simple biomarker for vascular disturbances in migraine.

Keywords:
ColdnessMigraineSkin blood flowSkin temperatureVasoconstriction

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Area of Science:

  • Neurology
  • Vascular Biology
  • Autonomic Nervous System

Background:

  • Migraine is a complex neurological disorder often accompanied by vascular disturbances.
  • Identifying reliable biomarkers for these vascular changes is crucial for understanding and managing migraine.

Purpose of the Study:

  • To investigate peripheral skin temperature differences between women with migraine and healthy controls.
  • To explore the potential of facial and hand skin temperatures as accessible biomarkers for vascular dysregulation in migraine.

Main Methods:

  • A comparative study involving 41 women (12 with migraine, 29 healthy controls) during headache-free periods.
  • Measurement of facial and hand (acral) skin temperatures in all participants.

Main Results:

  • Migraine patients demonstrated significantly lower acral skin temperatures compared to healthy controls.
  • A more pronounced reduction in skin temperature was observed in migraineurs with right-sided headaches.
  • Findings suggest a link between migraine and peripheral coldness, indicative of altered autonomic vascular control.

Conclusions:

  • Migraine is associated with peripheral coldness, potentially stemming from impaired autonomic vascular regulation.
  • Cold extremities (nose and hands) may serve as easily measurable biomarkers for vascular disturbances in migraine patients.