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Published on: November 10, 2017

Effect of simvastatin on hemostasis in patients with isolated hypertriglyceridemia

Robert Krysiak1, Boguslaw Okopien

  • 1Department of Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Pharmacology
|October 2, 2013
PubMed

Insights

Simvastatin treatment positively impacts blood clotting and clot breakdown in patients with high triglycerides. This statin therapy may offer benefits for individuals with elevated triglyceride levels and associated cardiovascular risks.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Pharmacology

Background:

  • Elevated triglyceride levels are linked to early-onset and accelerated coronary artery disease.
  • Hypertriglyceridemia is a significant risk factor for cardiovascular complications.

Purpose of the Study:

  • To investigate the effects of simvastatin on coagulation and fibrinolysis in patients with isolated hypertriglyceridemia.
  • To assess simvastatin's impact on hemostatic variables in this patient population.

Main Methods:

  • A 90-day randomized controlled trial involving 39 patients with hypertriglyceridemia and peripheral artery sclerosis.
  • Patients received either 40 mg daily simvastatin or a placebo.
  • Assessed plasma lipids, glucose homeostasis, and hemostatic variables at baseline and post-treatment.

Main Results:

  • Simvastatin significantly reduced plasma levels/activity of fibrinogen, factor VII, and plasminogen activator inhibitor-1.
  • No significant reduction in von Willebrand factor levels was observed with simvastatin.
  • Simvastatin tended to prolong prothrombin and partial thromboplastin times, indicating altered coagulation dynamics.

Conclusions:

  • Statin treatment, specifically simvastatin, exerts a multifaceted influence on coagulation and fibrinolysis.
  • These findings suggest potential cardiovascular benefits of simvastatin in patients with isolated hypertriglyceridemia.
Abstract

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