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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

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Published on: June 16, 2014

Deterioration in renal function is associated with increased arterial stiffness.

Merrill F Elias1, Adam Davey, Gregory A Dore

  • 1Department of Psychology, University of Maine, Orono, Maine.

American Journal of Hypertension
|October 2, 2013
PubMed
Summary

Higher pulse wave velocity (PWV) is linked to declining kidney function over time in community-dwelling adults. This study confirms the association between elevated PWV and reduced estimated glomerular filtration rate (eGFR).

Keywords:
blood pressurecardiovascular diseasechronic kidney diseaseestimated glomerular filtration ratehypertensionpulse wave velocityrenal disease.

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Area of Science:

  • Cardiovascular Health
  • Nephrology
  • Aging Research

Background:

  • Elevated pulse wave velocity (PWV) is a known indicator of arterial stiffness.
  • Previous studies linked higher PWV to kidney function decline in kidney disease patients.
  • The association in a general community sample was less understood.

Purpose of the Study:

  • To investigate the relationship between PWV and longitudinal decline in renal function.
  • To test the hypothesis that higher PWV is associated with declining renal function in a community-based sample.

Main Methods:

  • A 4-5 year longitudinal study of 482 community-living individuals (mean age 60.9 years).
  • Renal function assessed by estimated glomerular filtration rate (eGFR) and serum creatinine.
  • Multiple linear regression analyses adjusted for age, sex, cardiovascular risk factors, and other covariates.

Main Results:

  • Decline in renal function was significantly associated with higher PWV levels at follow-up.
  • The association persisted after adjusting for multiple potential confounders.

Conclusions:

  • Higher PWV is a predictor of longitudinal decline in renal function in a community sample.
  • Findings suggest PWV may serve as a marker for subclinical kidney function deterioration.