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Association between circulating endostatin, hypertension duration, and hypertensive target-organ damage

Axel C Carlsson1, Toralph Ruge, Johan Sundström

  • 1Centre for Family Medicine, Alfred Nobels Allé 12, 141 83 Huddinge, Sweden. axelcefam@hotmail.com; or Johan Ärnlöv, Department of Public Health and Caring Sciences/Geriatrics, Uppsala Science Park, SE-75185 Uppsala, Sweden. E-mail johan.arnlov@pubcare.uu.se.

Hypertension (Dallas, Tex. : 1979)
|October 2, 2013
PubMed

Insights

Elevated serum endostatin levels correlate with longer hypertension duration. Higher endostatin also indicates greater hypertensive target-organ damage, including heart and kidney issues.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Biochemistry

Background:

  • Long-term hypertension leads to cardiovascular and renal remodeling.
  • Circulating endostatin, derived from collagen XVIII, is a potential marker for extracellular matrix remodeling.
  • The role of endostatin in hypertension and associated target-organ damage remains unclear.

Purpose of the Study:

  • To investigate associations between circulating endostatin levels, hypertension duration, and hypertensive target-organ damage.
  • To explore endostatin as a potential biomarker in hypertension.

Main Methods:

  • Serum endostatin was measured in two independent community-based cohorts: PIVUS (n=812) and ULSAM (n=785).
  • Retrospective data on hypertension duration (>5 years in PIVUS, >27 years in ULSAM) and cross-sectional data on target-organ damage were analyzed.
  • Target-organ damage assessed included left ventricular mass, endothelial function, and urinary albumin/creatinine ratio.

Main Results:

  • Participants with longer hypertension duration showed significantly higher serum endostatin levels in both cohorts.
  • Higher endostatin levels were associated with increased left ventricular mass, impaired endothelial function, and elevated urinary albumin/creatinine ratio in hypertensive individuals.
  • These findings suggest endostatin is linked to hypertension duration and organ damage.

Conclusions:

  • Circulating endostatin is associated with hypertension duration.
  • Endostatin levels correlate with vascular, myocardial, and renal indices of hypertensive target-organ damage.
  • Further research is needed to determine the prognostic value of endostatin in hypertension.

Keywords:
Swedenangiogenesis effectsantiangiogenesis effectscohort studyendothelial cellsepidemiologyextracellular matrixvascular stiffness

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