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Multiple familial trichoepithelioma with malignant transformation.
Rehab M Samaka1, Ola A Bakry, Iman Seleit
1Department of Pathology, Andrology and S.T.Ds, Faculty of Medicine, Menoufiya University, Shebin Elkom, Egypt.
Indian Journal of Dermatology
|October 2, 2013
Summary
Multiple familial trichoepithelioma (MFT) is a rare autosomal dominant skin disease. This case highlights a rare instance of malignant transformation to basal cell carcinoma (BCC) in a patient with MFT.
Area of Science:
- Dermatology
- Oncology
- Genetics
Background:
- Trichoepithelioma (TE) is a benign follicular tumor, often presenting as facial papules.
- Multiple familial trichoepithelioma (MFT) is a rare autosomal dominant condition.
- Malignant transformation of TE to basal cell carcinoma (BCC) is exceptionally rare.
Purpose of the Study:
- To present a case of MFT with malignant transformation to BCC.
- To delineate key histological differences between TE and BCC.
- To utilize immunophenotyping to differentiate between TE and BCC.
Main Methods:
- Case presentation of MFT in a father and daughter.
- Histological analysis comparing TE and BCC.
- Immunophenotyping using Bcl2, CD34, CD10, and androgen receptor (AR) antibodies.
Main Results:
- The father with MFT exhibited malignant transformation to BCC.
- Distinct histological features differentiating TE and BCC were identified.
- Immunophenotyping provided differential markers between TE and BCC.
Conclusions:
- Malignant transformation in MFT, while rare, can occur.
- Histological and immunophenotypical analyses are crucial for distinguishing TE from BCC.
- This case underscores the importance of vigilance for malignant changes in MFT patients.
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