Related Experiment Video

Updated: May 7, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Symptom burden and job absenteeism after treatment with additional catheter-directed thrombolysis for deep vein

Tone Enden1, Nils-Einar Kløw, Per Morten Sandset

  • 1Department of Hematology, Oslo University Hospital, Oslo, Norway ; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway ; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Patient Related Outcome Measures
|October 2, 2013
PubMed

Insights

Additional catheter-directed thrombolysis (CDT) for deep vein thrombosis (DVT) improved symptoms and reduced leg swelling. While job absenteeism showed a trend towards reduction, further research is needed to confirm this benefit.

Area of Science:

  • Vascular Medicine
  • Interventional Radiology

Background:

  • Catheter-directed thrombolysis (CDT) for acute deep vein thrombosis (DVT) may offer a cost-effective alternative to standard treatment.
  • Accelerated thrombus resolution with CDT could improve acute phase symptoms and patient function.

Purpose of the Study:

  • To investigate if additional CDT reduces symptoms and job absenteeism in the first 6 months post-DVT treatment compared to standard care alone.

Main Methods:

  • A multicenter, open-label, randomized controlled trial (CaVenT study) involving patients aged 18-75 with high proximal DVT.
  • Patients received either additional CDT or standard treatment.
  • Quality of life and sickness benefits were assessed at baseline and 6 months.

Main Results:

  • Fewer patients in the CDT arm experienced leg swelling after 6 months compared to controls (29.4% vs. 49.0%, P=0.007).
  • A trend towards reduced job absenteeism was observed in the CDT arm, though not statistically significant when considering only working patients.
  • Mean job absenteeism duration showed a non-significant trend towards being longer in the CDT arm (86.4 days vs. 60.1 days, P=0.072).

Conclusions:

  • Additional CDT appears to improve symptom relief and reduce leg swelling in patients with acute DVT.
  • The findings suggest potential benefits in reducing job absenteeism, warranting further investigation.
Abstract

Keywords:
patient reported outcomespostthrombotic syndromerandomized controlled trialsymptom burdenthrombolytic therapyvenous thrombosis

More Related Videos

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug07:50

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Pulmonary Embolism III: Nursing Management01:27

Pulmonary Embolism III: Nursing Management

A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...